NEW YORK — With fresh COVID-19 cases bubbling up in some parts of the country, health officials are setting course for a fall vaccination campaign.

The Centers for Disease Control and Prevention on Thursday recommended new shots for all Americans this fall.

Officials acknowledged the need for shots is not as dire as it was only a few years ago. Most Americans have some degree of immunity from being infected, from past vaccinations or both. COVID-19 deaths and hospitalizations last month were at about their lowest point since the pandemic first hit the United States in 2020.

But immunity wanes, new coronavirus variants keep emerging and there are still hundreds of COVID-19-associated deaths and thousands of hospitalizations reported each week.

What’s more, health officials have reported upticks this month in COVID-19-associated emergency room visits and hospitalizations, and a pronounced increase in positive test results in the southwestern U.S.

It’s not clear whether that’s a sign of a coming summer wave — which has happened before — or just a blip, said Lauren Ancel Meyers of the University of Texas, who leads a research team that tracks COVID-19.

“We’ll have to see what happens in the coming weeks,” she said.

Earlier last month, the Food and Drug Administration — following the guidance of its own panel of expert advisers — told vaccine manufacturers to target the JN.1 version of the virus. But a week later, the FDA told manufacturers that if they could still switch, a better target might be an offshoot subtype called KP.2.

At a Thursday meeting at the CDC in Atlanta, infectious disease experts unanimously recommended the updated vaccines for Americans age 6 months and older. The CDC director signed off on the recommendation later in the day. The shots are expected to become available in August and September.

Health officials have told Americans to expect a yearly update to COVID-19 vaccines, just like they are recommended to get a new shot each fall to protect against the latest flu strains.